ŠKODA unveiled its all-electric VISION iV concept at the Geneva Motor Show, a crossover coupe based on Volkswagen’s MEB platform that “offers a look ahead at ŠKODA’s electric future.” more…The post ŠKODA debuts all-electric VISION iV concept appeared first on Electrek. Source: Charge Forward
Tesla Releases Full Model Y Reveal Video: Watch It Here Source: Electric Vehicle News Author Liberty Access TechnologiesPosted on March 20, 2019Categories Electric Vehicle News Why We Need To Be Underwhelmed By The Tesla Model Y Some say the Tesla Model Y reveal wasn’t that convincing. Others beg to differ.Tesla owner and YouTuber Andy Slye was one of many fans that were fortunate to attend the recent Tesla Model Y reveal. If you watched Trevor Page’s (Model 3 Owners Club) video coverage in our livestream article, you likely saw Andy enjoying himself at the event. He made it clear that he wasn’t attending with plans to place an order on a Model Y. Instead, he was just there to take it all in.More Tesla Model Y Content: Many reports have talked about the event’s lack of anticipated fanfare. Some have even gone so far as to say it was underwhelming. So, does this mean few people are going to actually purchase a Model Y?There’s really know way of knowing for sure at this point. However, if we look at the incredible popularity of the Tesla Model 3, it seems the Y is going to be at least as well-received, and likely much more popular. It’s essentially a Model 3 with greater versatility, and it’s priced well. To put it in perspective, the Model Y appears to be about the size of the Jaguar I-Pace, though it has considerably more cargo volume and offers third-row seating. Model Y variants will also offer more range than the I-Pace, and it has a starting price that’s over $20,000 less.Check out the video to learn what Andy thinks. Then, share your thoughts with us in the comment section below.Video Description via Andy Slye on YouTube:Why I Ordered A Tesla Model Y Even Though I Didn’t Want One: VideoTesla Model Y is an all-electric compact SUV with 300 miles of range. Is it worth buying?I attended the Tesla Model Y event last night in Hawthorne, CA. I was able to see the #ModelY up close and personal and even took a test ride in it. Here are my thoughts from a Model 3 owner’s perspective.Safety:Like every #Tesla , Model Y is designed to be the safest vehicle in its class. The low center of gravity, rigid body structure and large crumple zones provide unparalleled protection.Utility:Room for up to seven adults with optional third row. Versatile seating and storage for cargo and passengers. Easy access to the trunk makes loading and unloading convenient. #TeslaModelY provides maximum versatility—able to carry 7 passengers and their cargo. Each second row seat folds flat independently, creating flexible storage for skis, furniture, luggage and more. The liftgate opens to a low trunk floor that makes loading and unloading easy and quick.Dual Motor Option:Independent motors digitally control torque to the front and rear wheels. Quickest acceleration – from zero to 60 mph in as little as 3.5 seconds. Capable in rain, snow, mud and off-road with superior traction control. Tesla All-Wheel Drive has two ultra-responsive, independent electric motors that digitally control torque to the front and rear wheels—for far better handling, traction and stability control. Model Y is capable in rain, snow, mud and off-road.Range:300 miles: the longest electric range of any sport utility vehicle on the road. Recharge 168 miles in 15 minutes at Supercharger locations. 12K+ Superchargers placed along well-traveled routes around the world. Model Y is fully electric, so you never need to visit a gas station again. If you charge overnight at home, you can wake up to a full battery every morning. And when you’re on the road, it’s easy to plug in along the way—at any public station or with the Tesla charging network. We currently have over 12,000 Superchargers worldwide, with six new locations opening every week.Autopilot:All new Tesla cars come standard with emergency braking, collision warning, blind-spot monitoring and more. Model Y will have Full Self-Driving capability, enabling automatic driving on city streets and highways pending regulatory approval, as well as the ability to come find you anywhere in a parking lot.Interior:15” touchscreen and over-the-air software updates. With an elevated seating position and low dash, the driver has a commanding view of the road ahead. The interior of Model Y is simple and clean, with a 15-inch touch screen, immersive sound system and an expansive all-glass roof that creates extra headroom and provides a seamless view of the sky. Tesla Model Y: Everything We Know So Far, Plus Q&A: Video
The company says it’s adjusting the price because of outside influences.Source: Electric Vehicle News
The VW ID.R, an all-electric race car built by Volkswagen to beat some racing records, has officially run the fastest emission-free lap of all time on the Nürburgring-Nordschleife. more…Subscribe to Electrek on YouTube for exclusive videos and subscribe to the podcast.https://www.youtube.com/watch?v=V1zk7Eb8r-s&list=PL_Qf0A10763mA7Byw9ncZqxjke6Gjz0MtThe post VW ID.R electric racecar runs fastest emission-free lap of all time on the Nürburgring-Nordschleife appeared first on Electrek. Source: Charge Forward
Username Password Remember me How Brexit will impact businesses having a presence in or trading with the UK and the EU is still largely unknown and will remain so for some time. This article outlines the likely timeline of the UK’s withdrawal from the EU, how these will affect the regulatory landscape and the steps that Texas businesses may consider to deal with regulatory change . . .You must be a subscriber to The Texas Lawbook to access this content. Lost your password? Not a subscriber? Sign up for The Texas Lawbook.
« More Insanity from the Climate Group without Supporting Evidence QUESTION: Mr. Armstrong, in relating your comments on weather and how the winters will spike to record cold and then the summers will spike to record highs, is this the same as a panic cycle in markets?HCANSWER: Yes. Our computer looks at the weather the same as it does with the price in a market. Patterns emerge and you can understand the causes ONLY by correlating the trends with everything else. This is indeed a Panic Cycle where we exceed the previous high and penetrate the previous low. This coming weekend will see temperatures break 100 in the Northeast. I have lived in New Jersey and there were plenty of summers where we have days at 103. This is NOT abnormal. What is abnormal is the volatility how we can go from a winter where it was colder in Chicago than it was in Antarctica and then we break the record highs in July. It is the VOLATILITY – not the empirical level of temperature we should be paying attention to. Categories: Climate
Source:http://www.parkinsons.org.uk/ This study is the most robust evidence to date that there is a link between Parkinson’s and type 2 diabetes.The vast majority of people with diabetes will not go on to develop Parkinson’s. Studies that demonstrate type 2 diabetes is linked to an increased risk of Parkinson’s suggest, however, that the two conditions may affect cells in similar ways.Understanding the link between these two conditions could be key to developing treatments that slow the course of Parkinson’s, something that no current treatments can do.Currently, there is much interest in the potential for anti-diabetic drugs, such as exenatide, to slow the progression of Parkinson’s. The ability to repurpose these drugs, which are already used to treat people with diabetes, could speed up the delivery of new and better treatments to people with Parkinson’s who urgently need them.” Jun 14 2018A new study by UCL, University of Oxford and Queen Mary University of London researchers suggests that people with type 2 diabetes are 32% more likely to develop Parkinson’s disease than those without diabetes.Dr Beckie Port, Research Manager at Parkinson’s UK, said:
In the early 1900s, neurologist Korbinian Brodmann drew some of the first diagrams of the human cortex by hand, based on differences in cellular architecture that he could see under a microscope. For more than a century, scientists have continued using those maps, as well as those of neuroanatomists that followed in Brodmann’s footsteps. Now, neuroscientists have created a long-overdue update for those early diagrams, using anatomical and functional brain data from the Human Connectome Project—a large-scale, digitized effort to map the brain’s functions and structures from hundreds of human samples. Previous attempts at mapping the cortex—the wrinkly, outermost layers of the brain responsible for sensory and motor processing, language, and reasoning—have had mixed results because some were based on small samples and others focused on just one aspect of brain structure or function. To create a more detailed map, the team looked at four measures of structure and function, including the thickness and number of folds in the cortex and what activity different regions displayed in a functional magnetic resonance imaging scanner during a given task. They gathered their data from 210 healthy adults, and then trained a machine-learning algorithm to detect distinct regional “fingerprints.” The program defined 180 distinct areas, including nearly 100 that have never been described before, the scientists report today in Nature. The sharper, multilayered map will allow for more detailed comparisons between humans and other primates, shedding light on how our brains evolved, the scientists say. It could also prove a boon to neurosurgeons, as they decide where to insert their scalpels.
Meghan McCain Whines That She Can’t Attack llhan Omar Because Trump Is Too Racist Our condolences go out to Terrill Thomas’ family.SEE ALSO:Outrageous! Figurines Of White Cherub Crushing Head Of Black Angel Removed From Dollar StoreMeet Jogger Joe, The Man Who Took Racist Cue From BBQ Becky In Tossing Homeless Man’s ClothesDavid Clarke Has Sunken Place Meltdown After Cory Booker Destroys DHS Secretary On Live TV More By NewsOne Staff Black Lives Matter , David Clarke , Milwaukee Former Milwaukee County Sheriff David A. Clarke is one of President Donald Trump’s most loyal Black supporters. However, what is most important to know about him is, according to The Washington Post, at least four people died in the Milwaukee County jail that he managed from April 2015 to November 2016 — including a newborn baby whose birth occurred unbeknownst to staff. In a separate incident, his workers were accused of refusing to give water for a week to an inmate, who later died. The Most Ridiculous Photos From Trump’s Farce Of A Black History Month Celebration Now, the family of one of those victims is getting a massive settlement.SEE ALSO: David Clarke Retains Master’s Degree After Embarrassing Struggle To Correct PlagiarismAccording to The Associated Press, Milwaukee County paid nearly $7 million to settle a lawsuit from the family of Terrill Thomas “whose dehydration death in jail was described by his attorneys as torture.” The settlement went public this week but it was finalized in March.Attorneys for the family said, “The size of the settlement I believe reflected the tremendous pain and suffering that Mr. Thomas endured for days.” The attorneys also said it is one of the largest ever in Wisconsin for a jail death.Terrill Thomas, 38, was having a mental breakdown he was arrested on April 14, 2016. He allegedly shot a man in front of his parents’ home and then fire a gun inside a casino.While in jail, his water turned off because he supposedly flooded another cell by stuffing a mattress in the toilet. The Associated Press reports, “The water was never turned back on and he died a week later. He lost 34 pounds (15.5 kilograms), or 10 percent of his body weight, during the week he was deprived of water, according to the lawsuit.”Erik Heipt, a Seattle-based attorney who also represented Thomas’ family, said, “What happened to him was a form of torture. This sort of atrocity should never happen at an American jail. There’s no excuse for it.”The massive settlement will be split between Thomas’ six children (four are minors). The lawsuit against the jail, which, again, happened on David Clarke’s watch, is now dismissed. A$AP Rocky Being In A Swedish Prison Will Not Stop Her From Going To The Country That Showed Her ‘So Much Love’ Gov. Cuomo Slams Mayor Bill De Blasio For The Eric Garner Case But He Also Failed The Family
AddThis Sharing ButtonsShare to FacebookFacebookFacebookShare to TwitterTwitterTwitterShare to MoreAddThisMoreShare to EmailEmailEmail Joy Behar , Meghan McCain , The View 95 Photos Of Black People Marching For Our Lives Meghan McCain clearly can’t take the heat and it looks like she is ready to get out of the kitchen. There are reports that the 34-year-old is ready to leave “The View.”See Also: Ilhan Omar Reacts To Meghan McCain’s White TearsThe Daily Beast exclusively reports she can’t take all the bad press — meaning, she can’t handle when makes disgusting comments and people call her out. Sources claim she is “feeling like a caged animal” and she hates that she is seen as unreasonable, “manic” and “petulant child,” who has “crying fits” when she’s dragged on social media. After two seasons, McCain allegedly feels feels “so exhausted and defeated.” In addition, Abby Huntsman, who is currently on maternity leave, was supposedly hired by ABC to make Meghan “more comfortable.” Behar allegedly said, “If you want to know what white privilege looks like, this is a great example of it.”Well said.SEE ALSO:Meet Jogger Joe, The Man Who Took Racist Cue From BBQ Becky In Tossing Homeless Man’s ClothesTrump-Supporting DA Calls ‘Ghetto’ Maxine Waters A ‘Bitch,’ Can’t Believe She Hasn’t Been ShotThis Colin Kaepernick Retweet Says Everything You Need To Know About The NFL Players’ Anthem Grievance More By NewsOne Staff A so-called pal, which is probably someone on McCain team, told The Daily Beast, “It’s getting to the point where it’s not worth the emotional toll every week,” said a McCain pal, who asked not to be further identified. “If she doesn’t stay at The View, she will find other work.”The show’s executive producer Hilary Estey McLoughlin appeared to be defending her to The Daily Beast, “We don’t want people to attack Meghan. We’re happy to have Meghan there. I think she does want to be there. I think she wants to be on the show. She realizes it’s a very good platform for her and we love having her there. I feel like she will come back.”She then added, “What happens with Meghan is that because she’s so passionate about what she’s talking about, and she feels very strongly that she’s carrying this mantle for the conservative perspective, and what she wants to talk about is so important to her, I think that’s the part that’s the most draining for her.”Maybe McCain should stop being so evil and it would be easier on her. Back on June 19, she called 76-year-old Joy Behar a bitch on live television.However, this report isn’t too shocking. The heat on “The View” has allegedly been getting worse every day. According to a close source via The Daily Mail, “Whoopi is at her breaking point with Meghan. She’s been trying to hang in there, especially keep the peace with Meghan and Joy, but we all know she’s about to break.” A$AP Rocky Being In A Swedish Prison Will Not Stop Her From Going To The Country That Showed Her ‘So Much Love’ Gov. Cuomo Slams Mayor Bill De Blasio For The Eric Garner Case But He Also Failed The Family Meghan McCain Whines That She Can’t Attack llhan Omar Because Trump Is Too Racist
Photo by Diana HutchisonHigh winds in excess of 50 mph caused dust storms throughout the area last week. On Thursday, April 12, according to Navajo County, Snowflake had recorded wind gusts of 76 mph. Navajo County also issued a weather alert on Thursday for dust storms blowing across State Route 77 both north and south of Holbrook. High winds in excess of 50 mph caused dust storms RelatedSubscribe or log in to read the rest of this content. Bottom Ad April 17, 2018
Advertising P Rajagopal, Saravana Bhavan founder sentenced to life for murder, dies Related News New Zealand’s Finance Minister Grant Robertson speaks about the “wellbeing” budget in Wellington, New Zealand (Reuters)New Zealand unveiled plans on Thursday to spend up to NZ$3.8 billion ($2.47 billion) a year under its ‘wellbeing’ approach, which the government has touted as a new way of budgeting that moves beyond measuring just economic growth. Taking stock of monsoon rain ‘Uneven, two-paced’: Ex-cricketers slam pitch used in India-New Zealand semifinal The budget forecast an operating surplus of NZ$3.5 billion for the year ending June, up from NZ$1.7 billion forecast in December. The country’s debt is forecast to drop to 19.9% by 2022.GOALS MISSEDDespite enjoying a ‘rockstar’ economy for years, some New Zealanders have felt left behind due to the rising inequality.Ardern, the popular 38-year-old Prime Minister, came to power in 2017 with an agenda of social justice and promising to make the economy “work for all New Zealanders”.Some questioned whether the budget had lived up to the government’s stated goals to transform the economy and pointed out that the spending increase was still relatively modest as the government stuck firmly to its targets of paying down debt. More Explained Post Comment(s) Much of the excitement around the ‘wellbeing’ budget was dampened after some plans of Prime Minister Jacinda Ardern’s government were released earlier by the opposition party.The Labour-led government allocated over a billion dollars each for issues like mental health and child poverty. It also targeted funds towards tackling domestic violence, and for infrastructure projects like rail, hospitals and schools.“We are measuring our country’s success differently,” said Finance minister Grant Robertson. “We are not just relying on Gross Domestic Product (GDP), but also how we are improving the wellbeing of our people, protecting the environment and strengthening of our communities.” Tens of thousands of New Zealand teachers staged the country’s largest strike on Wednesday, and doctors, nurses and others also threatening industrial action this year for higher pay and shorter hours. By Reuters |Wellington | Updated: May 30, 2019 9:52:10 am After loss, New Zealand’s Jimmy Neesham tweets advising kids not to take up sports Chandrayaan-2 gets new launch date days after being called off “They have spent on their priorities that they stated they would but I just don’t get the sense that its the transformation that we have been promised,” said Ganesh Nana, chief economist at Wellington economic think tank BERL.Critics, many in the Labour’s left-wing base, already felt the government has already missed key opportunities to fulfill its transformative goals.Ardern made a surprise U-turn in April by ruling out a capital gains tax during her tenure, long a Labour policy to tackle wealth inequality. Advertising Ayodhya dispute: Mediation to continue till July 31, SC hearing likely from August 2 New Zealand can fire in semi-finals: Coach Gary Stead Advertising Best Of Express The budget increases annual operating allowance for new spending to $3.8 billion per year over the four-year forecast period, from $2.4 billion in the previous budget.The operating allowance for budget 2020 has also increased to $3.0 billion from $2.4 billion.The Treasury department downgraded its gross domestic product forecasts to 2.1% in the year ending June 30, 2019, compared to 2.9% predicted in December, hurt by a cooling global economy and slowing domestic consumption.GDP was forecast at 3.2% in fiscal 2020, and was seen averaging at about 2.6 percent over the forecasted four-year period.Robertson said the economy faces continuing risks from the U.S.-China trade disputes and Brexit.
China opens first overseas base in Africa: media reports Related News “The exercise met our expected objective. It is very significant for our unmanned logistics chain in future warfare,” said Bi Guangyuan, executive director of the exercise, CCTV reported.Chinese military analysts predicted that more unmanned transport aircraft could join the army’s logistics arsenal for long-range and heavy delivery in the future, state-run Global Times reported. “We … explored a new model of military cargo delivery in joint combat as well as in strategic and tactical logistics support,” Li said.Since transport planes usually do not need to make intense and complicated manoeuvres like fighter jets, even heavier cargo delivery missions could become unmanned if this technology becomes mature, a Chinese military expert told the Global Times.Airdrops often take place within the range of hostile anti-aircraft fire, so being unmanned lowers risk to life, the expert said.The exercise also means that the Chinese military now has the first large unmanned equipment in its logistics arsenal, the CCTV report said, noting that the mission was carried out on a plateau with a complicated terrain. By PTI |Beijing | Published: June 24, 2019 12:09:31 pm Best Of Express China says military drills ahead of Taiwan inauguration part of annual plan After Masood Azhar blacklisting, more isolation for Pakistan Advertising China developing world’s fastest armoured vehicle runs on both water and land Chinese military analysts predicted that more unmanned transport aircraft could join the army’s logistics arsenal for long-range and heavy delivery in the future, (REUTERS)The Chinese military has tested an unmanned transport plane that successfully delivered cargo at a designated area, making it a future prospect for airdropping cargo through parachutes in real battle conditions, official media here reported on Monday. Karnataka trust vote today: Speaker’s call on resignations, says SC, but gives rebel MLAs a shield Advertising Virat Kohli won’t have a say in choosing new coach Post Comment(s) Jointly held by the National Defence University of the People’s Liberation Army (PLA) and the state-owned China Aerospace Science and Technology Corporation, the aerial delivery exercise took place recently in Zhangye, Northwest China’s Gansu Province, China Central Television (CCTV) reported.The exercise featured an unmanned single-engine biplane, the designation of which was not revealed, as it carried a cargo of military supplies and successfully airdropped it into a target zone, according to the CCTV report.This is the first time China has conducted a parachuted aerial delivery of cargo weighing more than 500 kilograms on a flight distance of more than 500 kms with an unmanned transport aircraft, CCTV quoted Li Ruixing, the president of the PLA National Defence University’s joint logistics academy as saying.
Kenya Airways said Monday that police traced the body to its Nairobi-London flight.Police and airline officials say a stowaway fell from the landing gear of a jet as it approached London’s Heathrow Airport after a 9-hour flight from Nairobi. London Bridge attack suspect’s sister sacked from UK airport job The Metropolitan Police force says the body of an unidentified man was found in a south London garden on Sunday, and it’s believed he fell from a plane.He has not yet been identified.Kenya Airways said Monday that police traced the body to its Nairobi-London flight. A bag, water and food were discovered in the plane’s landing-gear compartment.Though not common, stowaways have in the past plunged to the streets of London as planes lowered their landing gear. In September 2012, a 30-year old from Mozambique, Jose Matada, died after falling from the undercarriage of a Heathrow-bound flight from Angola. Several UK flights cancelled as Hurricane Gonzalo strikes Related News Man stabs himself in front of passengers with knife bought at Heathrow Airport Advertising By AP |London | Published: July 1, 2019 11:10:09 pm 2 Comment(s)
Reviewed by James Ives, M.Psych. (Editor)Dec 19 2018Scientists say more should be done to tackle the growing environmental impact of takeaway food containers.A new study estimates there are 2025 million takeaway containers per year being used in the European Union (EU) alone. It also says finding a way to recycle disposable takeaway containers could help reduce equivalent greenhouse gas emissions generated annually by 55,000 cars.The researchers, from The University of Manchester, have carried out the first ever comprehensive study of the environmental impacts of disposable takeaway-food containers. They looked at aluminium, polystyrene (styrofoam) and polypropylene (clear plastic) containers. These were compared to reusable plastic containers, such as “Tupperware”.For example, the study found that whilst Styrofoam containers have the lowest carbon footprint – 50% lower than aluminium containers and three times lower than their plastic counterparts – they cannot be considered a sustainable packaging as they are not recycled at a mass level and often end up in landfill.The global takeaway food market is growing fast, with a projected value of over £80 billion in 2020. The sector uses a vast amount of disposable takeaway containers, estimated in this study at 2025 million units per year in the European Union (EU) alone.Despite this, the scale of the impacts on the environment of takeaway-food containers used in this growing sector was not measured until now.The study used life cycle assessment (LCA) to estimate the impacts of containers, taking into account their manufacture, use and end-of-life waste management. Altogether, the research team investigated 12 different environmental impacts, including climate change, depletion of natural resources and marine ecotoxicity.The study found that the styrofoam container was the best option among the disposable containers across all the impacts considered, including the carbon footprint. For example, the styrofoam container had 50% lower carbon footprint than aluminium and three times lower than the plastic. This is because of the lower amount of materials and energy used in the production of styrofoam compared to the other two types of container.Related StoriesResearch sheds light on sun-induced DNA damage and repairAXT enhances cellular research product portfolio with solutions from StemBioSysSchwann cells capable of generating protective myelin over nerves finds researchHowever, styrofoam containers are currently not recycled and cannot be considered a sustainable packaging option. The study estimates that recycling half of the containers currently in use, as envisaged by the EU recycling policy for the year 2025, would reduce their carbon footprint by a third. This would save 61,700?t CO2 eq. per year at the EU level, equivalent to the greenhouse gas emissions generated annually by 55,000 cars. Most other impacts would be reduced by more than 20%.Dr Alejandro Gallego-Schmid, the lead author, explains: ‘Achieving this level of recycling of styrofoam containers is going to be challenging. Although technically possible and practiced at small scale in some countries, the main difficulties are related to collecting the used containers and the associated costs.’Dr Joan Fernandez Mendoza, one of the study authors, added: ‘Because they are so light, the styrofoam containers can easily be blown away, contributing to urban and marine litter. So, despite their lower life cycle environmental impacts relative to the other containers, styrofoam containers cannot be considered a sustainable packaging option unless they can be recycled at a large scale.’The study also found that reusable Tupperware containers had a lower carbon footprint than disposable styrofoam when they were reused more than 18 times. This is despite the energy and water used for their cleaning. Disposable clear-plastic containers needed to be reused even fewer times – only five – to become better for the carbon footprint than the styrofoam.Professor Adisa Azapagic, the project leader, commented: ‘As consumers, we can play a significant role in reducing the environmental impacts of food packaging by reusing food containers as long as possible. Our study shows clearly that the longer we reuse them, the lower their impacts become over their extended lifetimes.’ Source:https://www.manchester.ac.uk/
Powassan virus, a member of the flavivirus family to which Zika belongs, is still rare, but it can be deadly–and as with many emerging diseases, there was previously no known prevention or treatment for it. This new vaccine is based on a vaccine platform that Diamond and his colleagues used to develop a potential vaccine for Zika: mRNA from the virus in question, encapsulated in lipid nanoparticles (LNP), produces subviral particles that share many features of the virus and provoke an immune reaction that produces protective antibodies. In mice, the new vaccine was effective after one dose against two different strains of Powassan virus and against the more distantly related Langat virus.This work suggests that the LNP-encapsulated modified mRNA vaccine platform could be used to produce vaccine candidates for other flaviviruses by substituting in mRNA from the virus the researchers want to target. Diamond and his colleagues hope that this could be a way to rapidly produce potential vaccines for new flaviviruses as they emerge and before they become epidemics.”We are excited that this mRNA-based vaccine against Powassan virus was highly immunogenic and conferred protection against multiple members of the family. We plan to continue studying the molecular basis for its broadly neutralizing antibody activity and test the vaccine against additional related viruses,” he says.Source: https://www.cell.com/ Dec 27 2018A group of researchers led by Michael Diamond of Washington University in St. Louis have developed a vaccine that is effective in mice against Powassan virus, an emerging tick-borne virus that can cause life-threatening encephalitis in humans. They also show that the vaccine produces antibodies that can protect the mice against other, related tick-transmitted flaviviruses. Their findings appear December 18 in the journal Cell Reports.
Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) that is most frequently seen in young adults. It is a chronic illness, of which the severity is classified as mild-to-moderate or moderate-to-severe. Most patients experience mild-to-moderate symptoms, with periods of remission and relapse. About 15 to 30 percent of patients with IBD have a family member with the disease. There is research underway to find out if a certain gene or a group of genes makes a person more likely to have IBD.The guideline is accompanied by a technical review: that is a compilation of the clinical evidence based on which these recommendations were framed. Reviewed by Kate Anderton, B.Sc. (Editor)Jan 10 2019Most patients with ulcerative colitis (UC) have mild-to-moderate disease characterized by periods of activity or remission, but practice variations exist in disease management. A new clinical guideline from the American Gastroenterological Association (AGA) published in Gastroenterology, the official journal of AGA, addresses the medical management of these patients, focusing on use of both oral and topical 5-aminosalicylates (5-ASA) medications, rectal corticosteroids and oral budesonide, to promote high-quality care for UC patients.AGA’s new clinical guideline is meant to help with the management of patients with mild-to-moderate UC, but not all patients will effectively respond to the outlined therapies. In those cases, there may be a need to escalate treatment to systemic corticosteroids, immunomodulators and/or biologic therapies for induction and maintenance of remission. However, the use of biologic therapies and/or immunomodulators are not specifically addressed within the guideline.Mild-to-moderate UC was defined as patients with fewer than four to six bowel movements per day, mild or moderate rectal bleeding, absence of constitutional symptoms, low overall inflammatory burden, and absence of features suggestive of high inflammatory activity. Although disease activity exists on a spectrum, patients in the mild-to-moderate category who have more frequent bowel movements, more prominent rectal bleeding or greater overall inflammatory burden should be considered to have moderate disease.The guideline recommends the following for the medical management of mild-to-moderate UC: Use either standard dose mesalamine (2-3 grams/day) or diazo-bonded 5-ASA rather than low dose mesalamine, sulfasalazine or no treatment in patients with extensive mild-moderate UC. (Strong recommendation, moderate quality evidence) In patients with extensive or left-sided mild-moderate UC, add rectal mesalamine to oral 5-ASA. (Conditional recommendation, moderate quality evidence) In patients with mild-moderate UC with suboptimal response to standard-dose mesalamine or diazo-bonded 5-ASA or with moderate disease activity, use high-dose mesalamine (>3 g/d) with rectal mesalamine. (Conditional recommendation, moderate-quality evidence [induction of remission], low-quality evidence [maintenance of remission]) In patients with mild-moderate UC being treated with oral mesalamine, use once-daily dosing rather than multiple times per day dosing. (Conditional recommendation, moderate quality evidence) In patients with mild-moderate UC, use standard-dose oral mesalamine or diazo-bonded 5-ASA, rather than budesonide MMX or controlled ileal-release budesonide for induction of remission. (Conditional recommendation, low quality of evidence) In patients with mild-moderate ulcerative proctosigmoiditis or proctitis, use mesalamine enemas (or suppositories) rather than oral mesalamine. (Conditional recommendation, very-low-quality evidence) In patients with mild-moderate ulcerative proctosigmoiditis who choose rectal therapy over oral therapy, use mesalamine enemas rather than rectal corticosteroids. (Conditional recommendation, moderate-quality evidence) In patients with mild-moderate ulcerative proctitis who choose rectal therapy over oral therapy, use mesalamine suppositories. (Strong recommendation, moderate-quality evidence) In patients with mild-moderate ulcerative proctosigmoiditis or proctitis being treated with rectal therapy who are intolerant of or refractory to mesalamine suppositories, use rectal corticosteroid therapy rather than no therapy for induction of remission. (Conditional recommendation, low-quality evidence) In patients with mild-moderate UC refractory to optimized oral and rectal 5-ASA, regardless of disease extent, add either oral prednisone or budesonide MMX. (Conditional recommendation, low-quality evidence) In patients with mild-moderate UC , AGA makes no recommendation for use of probiotics. (No recommendation, knowledge gap) In patients with mild-moderate UC despite 5-ASA therapy, AGA makes no recommendation for use of curcumin. (No recommendation, knowledge gap) In patients with mild-moderate UC without Clostridium difficile infection, AGA recommends fecal microbiota transplantation be performed only in the context of a clinical trial. (No recommendation for treatment of ulcerative colitis, knowledge gap) Source:https://www.gastro.org/press-release/new-guideline-provides-recommendations-for-the-treatment-of-mild-to-moderate-ulcerative-colitis